Cell and Molecular Biology Cluster
The CMB cluster has three main goals. 1) Coordinate course offerings in the areas of cell and molecular biology to ensure critical subject areas are available to graduate students who have joined a participating research group. 2) Build a cross-campus community of research groups to promote intellectual exchange, collaborative opportunities, and sharing of technical expertise. 3) Provide advanced training in both fundamental and novel experimental approaches through short, intensive practicum classes.
Curriculum
Students pursuing the CMB Cluster will be expected to take either Cell Biology DGP 405 or IBIS 406 and one of the following molecular biology classes, Molecular Biology DGP 410, Eukaryotic Molecular Biology DGP 462, or Eukaryotic Molecular Biology IBIS 402. Students who have not taken statistics can either take an appropriate statistics course or Quantitative Biology IBIS 410. (This latter requirement is in keeping with the NIH directive to improve quantitative training of biology graduate students.) These course requirements will provide a common vocabulary and intellectual grounding for all the students within the cluster.
By the end of the third year, students will be expected to have taken two advanced topics courses. These will be offered by faculty or teams of faculty and will explore the current literature in selected areas.
Community Activities
The cluster will have quarterly meetings that alternate between campuses. Anchoring the meeting are lectures from a faculty member from each campus and a poster session with light refreshments. Roughly one third of the graduate students are expected to present a poster at each meeting enabling all students to present once a year. Travel awards will be given to the students with the best posters.
Advanced Training
The fields of cell and molecular biology have been undergoing a revolution in the available experimental approaches and their sophistication. For even a large well-funded laboratory, it is very difficult to stay current with the latest technology in multiple areas. To address these needs, the CMB cluster will sponsor short practical classes in these emerging research areas. Appropriate topics include: advanced light microscopy, cryo-EM, mass spec, protein purification, bioinformatics, and high-throughput analysis. To provide these short courses, we will partner with local experts, relevant on campus facilities, and outside experts.
Cluster Co-directors
- Vladmir Gelfand, PhD Professor, Cell and Molecular Biology
- Robert Holmgren, PhD Professor, Molecular Biosciences
- Eric L Weiss, PhD Assistant Professor, Molecular Biosciences
Training Faculty
- Hossein Ardehali, MD, PhD (DGP) Role of mitochondria in ischemic heart disease and cell death
- James Bartles, PhD (DGP) Espin actin-bundling proteins, hair cell stereocilia, sensory neuroscience
- Joseph Bass, MD/PhD (IBiS and DGP) Genetic and genomic analysis of glucose metabolism and insulin resistance
- Lester Binder, PhD (DGP) The role of the cytoskeleton in neurodegeneration
- Jason H Brickner, PhD (IBiS) Spatial organization of the nucleus and the expression of genes
- Thomas Bozza, PhD (IBiS) Molecular Genetics and Physiology of Olfaction
- Richard Carthew, PhD (IBiS) RNAi and Gene Regulation
- Anjen Chenn, MD, PhD (DGP) Developmental Neurobiology: Regulation of Cell Fate and Cell Proliferation in the Mammalian CNS
- Joan Cook-Mills, PhD (DGP) Endothelial cell function during allergic disease
- Seth Corey, MD, MPH (DGP) Role of Src family protein kinases in proliferation and cytoskeletal reorganization
- Vincent Cryns, MD (DGP) Molecular Mechanisms of Cancer Cell Death (Apoptosis)
- David M. Engman, Ph.D. (DGP) Organelle Biogenesis in Trypanosomes
- Adriana Ferriera, MD, PhD (DGP) Cellular and molecular mechanisms of neurite elongation in central neurons
- Jaime Garcia-Anaveros, PhD (DGP) Genetic dissection of hearing, touch and pain in mammals and in the nematode Caenorhabditis elegans
- Vladmir Gelfand, PhD (DGP) Cytoskeleton assembly and function; biochemistry of microtubules; mechanisms and regulation of intracellular transport
- Spiro Getsios, PhD (DGP) Cell-cell adhesion and communication in development and disease
- Robert Goldman, PhD (DGP) Structure and function of cytoskeletal intermediate filament
- Cara Gottardi, PhD (DGP) Cell-cell adhesion and differentiation by the cadherin/catenin system
- Kathleen Green, PhD (DGP) Intercellular adhesion in differentiation, cancer, skin and heart disease
- Ann Harris, PhD (DGP) Chromatin Structure and the Regulation of Gene Expression; Pancreas Cancer
- Linda Hicke, PhD (IBiS) Monoubiquitin regulation of signaling receptors through the endocytic pathway
- Robert Holmgren, PhD (IBiS) Cell-fate specification during development
- Curt M Horvath, PhD (IBiS) Signal transduction and gene regulation in innate immune responses to cancer and viruses
- Sui Huang, PhD (DGP) The Perinucleolar Compartment and Malignant Transformation
- Jonathan Jones, PhD (DGP) Cell-matrix adhesion, motility and signaling
- Steven Kosak, PhD (DGP)Nuclear Form and Function in Cell Fate Decisions
- Carole LaBonne, PhD (IBiS) Formation, migration and differentiation of neural crest cells
- Robert A Lamb, PhD, ScD (IBiS) Viral Glycoproteins, Ion Channels, and RNA-Binding Proteins
- Brian Layden, MD, PhD (DGP) Role of free fatty acid receptors and ligands in obesity and diabetes
- Yong Chao Ma, PhD (DGP) Regulation of Motor Neuron and Dopaminergic Neuron Differentiation in Development and Disease
- Andreas Matouschek, PhD (IBiS) Mechanisms of Macromolecular Machines
- Franck Mauvais-Jarvis, MD, PhD (DGP) Estrogen and androgen actions in diabetes and obesity
- Kelly Mayo, PhD (IBiS) Cell signaling and gene expression in the mammalian reproductive axis
- William M. Miller, PhD (IBiS) Regulation of hematopoietic stem cell self-renewal and lineage commitment
- Brian Mitchell, PhD (DGP) Basal body duplication and the generation of cilia planar polarity
- Thomas O’Halloran, PhD (IBiS) Molecular mechanisms of metal-responsive gene expression
- Carol Podlasek, PhD (DGP) Sonic hedgehog (SHH) signaling in penile development and erectile dysfunction
- Murali Prakriya, PhD (DGP) Intracellular Calcium Signaling
- Ishwar Radhakrishnan, PhD (IBiS) Structure, function, dynamics and informatics of macromolecular complexes
- Sarah Rice, PhD (DGP) Functions of Molecular Motor Tails
- Vijay Sarthy, PhD (DGP) Gene regulation, development and functional organization of the vertebrate retina
- Hans-George Simon, PhD (DGP) Development and regenerative repair of vertebrate limbs and hearts
- Erik J Sontheimer, PhD (IBiS) Ribonucleoproteins and Eukaryotic Gene Expression
- Edward Thorp, PhD (DGP) Inflammation Resolution and Repair in Cardiovascular Disease
- Vinzenz Unger, PhD (IBiS) Mechanisms of membrane associated processes
- John Varga, MD (DGP) TGF-ß and the Pathogenesis of Fibrosis
- Eric L Weiss, PhD (IBiS) Signaling Pathways in the Control of Cell Architecture
- Sadie Wignall, PhD (IBiS) Spindle assembly and chromosome segregation during cell division
- Catherine Woolley, PhD (IBiS) Hormonal Effects on Hippocampal Synaptic Structure and Function
- Jing Zheng, PhD (DGP) Deafness-related proteins, cochlear amplification, cell death and differentiation

