Chemical Biology and Drug Discovery
The Chemical Biology and Drug Discovery cluster provides a multidisciplinary platform for students to learn the fundamental aspects of modern drug discovery and related molecular sciences focused on the modulation of biological systems. Trainees from both the life and chemical sciences acquire necessary skills and knowledge in the diverse topical areas related to contemporary drug discovery and integrative chemical biology, while delving more deeply into their respective disciplinary education and their own area of research interest. In this regard, the curriculum is customizable to the individual student’s goals and leverages the established and nationally recognized chemical biology and drug discovery training environment. For example, areas of significant interest is the outstanding expertise in the application of molecular sciences to the development of small molecules for use in complex biological systems and the identification of molecular targets in signal transduction or disease progression pathways amenable to therapeutic intervention.
Students in the Chemical Biology and Drug Discovery cluster are encouraged to customize their formal coursework to acquire a firm foundation in areas key to his or her career development. To augment formal classroom instruction, students are encouraged to participate in key activities such as the Annual Drug Discovery Symposium held each fall and the Visiting Lecture Series. Specialized workshops in specialized areas of interest are also offered at times based on planning with students, fellows and faculty interested in cross-disciplinary training or advanced specialized education.
For more information about drug discovery at Northwestern University please visit the Center for Molecular Innovation and Drug Discovery website HERE.
Cluster Directors
- Karl Scheidt, PhD, Associate Professor, Chemistry
Drug Discovery Faculty Members
* Denotes IBiS and DGP Training Faculty
- Wayne Anderson*, PhD (DGP) The Structural Basis of Protein Functions
- Raymond Bergan*, MD (DGP) Therapeutic modulation of adhesion and motility in human prostate cells
- Lester Binder*, PhD (DGP) The role of the cytoskeleton in neurodegeneration
- Christine DiDonato*, PhD (DGP) Molecular basis of spinal muscular atrophy (SMA)
- John Disterhoft, PhD (NUIN) Neurobiology of associative learning
- David Engman*, MD, PhD (DGP) Molecular Pathogenesis of Infectious and Autoimmune Heart Diseases
- William Karpus*, PhD (DGP) Chemokines in Autoimmunity, Infectious Disease, and Lymphoma Metastasis
- Neil L. Kelleher*, PhD (IBiS) Nuclear Signaling and Natural Products
- Anthony Kossiakoff, PhD, (Univ. of Chicago) Professor, Biochemistry & Molecular Biology
- Mary Jo LaDu, PhD, (Univ. Illinois Chicago) Anatomy and Cell Biology
- Robert A. Lamb*, PhD, ScD (IBiS) Viral Glycoproteins, Ion Channels, and RNA-Binding Proteins
- Yong-Chao Ma, PhD (DGP) Regulation of Motor Neuron and Dopaminergic Neuron Differentiation in Development and Disease
- Thomas Meade*, PhD (IBiS) Inorganic coordination chemistry for the study of molecular imaging
- Marek-Marsel Mesulam, MD (NUIN) Networks that mediate spatial attention
- Stephen Miller*, PhD (DGP) Immunoregulation of T Cell-Mediated Autoimmune and Virus Diseases
- Alfonso Mondragon*, PhD (IBiS) DNA topoisomerases, catalytic RNA molecules, and the molecular basis of spectrin flexibility
- Richard Morimoto*, PhD (IBiS) Chaperone Networks and Mechanisms of Protein Conformational Disease
- Thomas O'Halloran*, PhD (IBiS) Metalloregulatory proteins; molecular mechanisms of metal-responsive gene expression; protein-DNA interactions; oxygen activation by nonheme iron proteins; bioinorganic chemistry
- Murali Prakriya*, PhD (DGP) Intracellular Calcium Signaling
- Sarah Rice*, PhD (DGP) Functions of Molecular Motor Tails
- Steven Rosen*, MD (DGP) Biologic therapies of cancer
- Karl Scheidt*, PhD (IBiS) Drug discovery, bioorganic chemistry, and small molecule-driven chemical biology
- Teepu Siddique*, MD (DGP) Molecular basis of neurodegeneration and amyotrophic lateral sclerosis
- Richard Silverman*, PhD (IBiS) Bioorganic, medicinal, and enzyme chemistry: investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents, particularly for neurodegenerative diseases
- D. James Surmeier, Jr., PhD (NUIN) Neuromodulators and the excitability of basal ganglia and frontal cortex neurons
- Regan Thomson, PhD (Chemistry) Total synthesis of topologically complex polycyclic natural products
- Robert Vassar*, PhD (DGP) Molecular Mechanisms of Alzheimer's Disease
- D. Martin Watterson*, PhD (DGP) Signal Transduction, Integrative Chemical Biology and Drug Discovery
- Phyllis Zee, MD, PhD (NUIN) Effects of age on sleep and circadian rhythms

