2nd Annual Genetics and Genomics Symposium
Baldwin Auditorium
Friday, March 30, 2012
11:00 AM – 5:00PM
Genetics and Genomics
Genetics, the science of inheritance and variation among living organisms, can be traced back to the seminal work of Gregor Mendel, published in 1866. Yet today genetics is one of the most fast-moving fields of biomedical research. Technological progress driven by the relatively new science of genomics, the study of the genomes of organisms, has led to rapid advances over the past few years. We now have the complete DNA sequence of many genomes and are able to decipher the mechanisms that regulate gene expression, configure chromatin architecture, recruit transcription factors and activate or silence individual loci or gene networks. Moreover, we can investigate the cross-talk between the genome and the epigenome, the modifications that alter gene expression but do not change the underlying DNA sequence. These dynamic processes are critical for normal development and differentiated function of distinct cell types in an organism and their failure results in a wide spectrum of human diseases.
Northwestern University is home to a vibrant and interactive group of scientists carrying out world-class, state-of-the-art research into fundamental mechanisms of genetics, genomics and epigenomics. The Genetics and Genomics cluster enhances and builds advanced training for our graduate students in these subject areas. This is an inclusive training opportunity that is available to all trainees on the several university campuses, irrespective of their primary field of study, or their departmental or geographical affiliations.
Training opportunities include:
1. Special Topics Colloquia. The advanced colloquium will form the main training event for the cluster and feature the strength and breadth of our faculty.
2. State of the art workshops. These will take place once per quarter and will focus on a field of genetics, gene expression and genomics with dramatic recent advances.
3. Genetics and Genomics seminars. The seminar speakers of international reputation will be chosen and invited by the trainees. Other relevant seminar series and journal clubs are ongoing.
4. Annual Symposium. This half-day event will be organized jointly by the cluster steering group and the trainees and will provide an opportunity for the students to show case their work and get to know more about Genetics and Genomics related activities across Northwestern.
Cluster Director
- Ann Harris, PhD Professor, Pediatrics, Director, Human Molecular Genetics Program, CMRC
Training Faculty
* Denotes Training Faculty for PhD students1. Chromatin and Epigenetics.
- Jason Brickner*, PhD (IBiS) Spatial organization of the nucleus and gene expression
- Debabrata Chakravarti*, PhD (DGP) Hormone signaling and chromatin modifications
- John Crispino*, PhD (DGP) Transcriptional regulation of normal and malignant blood cell development
- Ann Harris*, PhD (DGP) Chromatin Structure and the Regulation of Gene Expression
- Laura Herzing*, PhD (DGP) Epigenetic control of gene expression in neurodevelopmental, psychiatric and seizure disorders
- Steve Kosak*, PhD (DGP) Nuclear Form and Function during Cellular Differentiation and Disease
- John Marko*, PhD (IBiS) Protein-DNA interactions, and chromosome structure and dynamics
- Christopher Payne*, PhD (DGP) Epigenetics of Stem Cells and the Stem Cell Niche
- M Bento Soares*, PhD (DGP) Genomic instability, aberrant transcription and splicing in tumorigenesis and cancer metastasis
- Tom Volpe, PhD Heterochromatin Formation in Higher Eukaryotes
2. Regulation of Gene Expression and Transcription Factors.
- Ravi Allada*, MD (IBiS) Molecular Genetics of Sleep and Circadian Rhythms
- Jason Brickner*, PhD (IBiS) Spatial organization of the nucleus and gene expression
- Melissa Brown*, PhD, (DGP) Expression of interleukin 4 (IL-4) and its role in normal and autoimmune responses
- Debabrata Chakravarti*, PhD (DGP) Hormone signaling and chromatin modifications
- John Crispino*, PhD (DGP) Transcriptional regulation of normal and malignant blood cell development
- Ann Harris*, PhD (DGP) Chromatin Structure and the Regulation of Gene Expression
- Geoff Kansas*, PhD (DGP) Molecular Biology of Leukocyte Adhesion and Migration
- Steven Kosak*, PhD (DGP) Nuclear Form and Function during Cellular Differentiation and Disease
- Carole LaBonne*, PhD (IBiS) Formation, migration and differentiation of neural crest cells
- Jonathan Licht*, MD (DGP) Transcription Factors Disrupted In Human Cancer - Mechanism Of Action And Targets
- William Lowe*, MD (DGP) IGF-1 Gene Expression and Genetics of Diabetes
- Yong Chao Ma*, PhD (DGP) Regulation of Motor Neuron and Dopaminergic Neuron Differentiation in Development and Disease
- Christopher Payne*, PhD (DGP) Epigenetics of Stem Cells and the Stem Cell Niche
- Marcus Peter*, PhD (DGP) miRNAs in tumor progression
- Hans-Georg Simon*, PhD (DGP) Development and regenerative repair of vertebrate limbs and hearts
- Erik Sontheimer*, PhD (IBiS) Ribonucleoproteins and Eukaryotic Gene Expression
- Warren Tourtellotte*, MD, PhD (DGP) Immediate early gene function in the nervous system
- Eric Weiss*, PhD (IBiS) Signaling Pathways in the Control of Cell Architecture
3. Animal Models for Human Genetic Disease.
- Greg Beitel*, PhD (IBiS) Molecular Genetics of Organ Morphogenesis
- Thomas Bozza*, PhD (IBiS) Molecular Genetics and Physiology of Olfaction
- Richard Carthew*, PhD (IBiS) RNAi and Gene Regulation
- Christine DiDonato*, PhD (DGP) Molecular basis of spinal muscular atrophy (SMA)
- Laura Herzing*, PhD (DGP) Epigenetic control of gene expression in neurodevelopmental, psychiatric and seizure disorders
- Robert Holmgren*, PhD (IBiS) Cell-fate specification during development
- Michael Kluppel*, PhD (DGP) Chondroitin sulfate in growth factor signaling, development and cancer
- Carole LaBonne*, PhD (IBiS) Formation, migration and differentiation of neural crest cells
- Brian Layden, MD, PhD (DGP) Role of free fatty acid receptors and ligands in obesity and diabetes
- Hans-Georg Simon*, PhD (DGP) Development and regenerative repair of vertebrate limbs and hearts
- Fred Turek*, PhD (IBiS) Sleep and Circadian Rhythms
- Xiaozhong (Alec) Wang*, PhD (IBiS) Genetic Analysis of Protocadherin Diversity in the Central Nervous System
4. Novel Genetic Technologies and Bioinformatics.
- Luis Amaral*, PhD (IBiS) Integrative approach to modeling cellular signaling pathways
- Rex L. Chisholm*, PhD (DGP) Molecular Motors and Cell Motility
- John Crispino*, PhD (DGP) Transcriptional regulation of normal and malignant blood cell development
- Warren Kibbe, PhD Bioinformatics
- Steven Kosak*, PhD (DGP) Nuclear Form and Function during Cellular Differentiation and Disease
- Simon Lin, MD, CSDP, Bioinformatics Core Facility Director
- Ishwar Radhakrishnan*, PhD (IBiS) Structure, function, dynamics and informatics of macromolecular complexes
- M Bento Soares*, PhD (DGP) Genomic instability, aberrant transcription and splicing in tumorigenesis and cancer metastasis
- San Ming Wang, MD Genome sciences
- Ji-Ping Wang, PhD Bioinformatics and genomics
5. Genetics of Complex disease.
- Ravi Allada*, MD (IBiS) Molecular Genetics of Sleep and Circadian Rhythms
- Joseph Bass*, MD, PhD (DGP & IBiS) Genetic and genomic analysis of glucose metabolism and insulin resistance
- Han-Xiang Deng, MD, PhD
- Pablo Gejman, MD Genetic basis of schizophrenia
- M Geoffrey Hayes, PhD Evolutionary population genetics and genetic epidemiology
- Spencer Huang, PhD Gene expression analysis with application to cancer research
- Peter Kopp*, MD (DGP) Molecular genetics of thyroid and other endocrine disorders
- William Lowe*, MD (DGP) IGF-1 Gene Expression and Genetics of Diabetes
- Teepu Siddique*, MD (DGP) Molecular basis of neurodegeneration and amyotrophic lateral sclerosis
- Margrit Urbanek*, PhD (DGP) Susceptibility genes for complex diseases
- John Varga*, MD (DGP) TGF-ß and the Pathogenesis of Fibrosis
- Xiaobin Wang, MD, MPH, ScD Molecular epidemiology for child growth and development
- Barbara Burton, MD Inborn errors of metabolism
- Lawrence Jennings, MD, PhD Novel molecular assays
- Peter Kopp*, MD (DGP) Molecular genetics of thyroid and other endocrine disorders
- Suzanne O’Neill, MS, PhD, CGC Quantitative genetics
- Wendy Rubinstein, MD, PhD Hereditary cancer syndromes
- Maureen Smith, MS, CGC Genome-wide Studies
- Cathy Wicklund, MS, CGC Genetic Counseling
- Laurie Zoloth, PhD Bioethics

